Linaclotide

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Chemical Structure| 851199-59-2 同义名 : Linaclotide游离态
CAS号 : 851199-59-2
货号 : A696508
分子式 : C59H79N15O21S6
纯度 : 99%
分子量 : 1526.74
MDL号 : MFCD20526656
存储条件：

Pure form Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(32.75 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 15 mg/mL(9.82 mM)，配合低频超声，并调节pH至2
动物实验配方：
生物活性
描述 Linaclotide is a 14-amino acid peptide indicated for the treatment of adults with CC and IBS-C and an agonist of guanylate cyclase C
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.65mL

0.13mL

0.07mL

3.27mL

0.65mL

0.33mL

6.55mL

1.31mL

0.65mL
参考文献

[1]Love BL, Johnson A, et al. Linaclotide: a novel agent for chronic constipation and irritable bowel syndrome. Am J Health Syst Pharm. 2014 Jul 1;71(13):1081-91.

[2]Bryant AP, Busby RW, et al. Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract. Life Sci. 2010 May 8;86(19-20):760-5.