产品说明书
D-Glucurono-6,3-lactone
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同义名 : | 葡糖醛酸內酯 ;D-Glucuronolactone;Dicurone;Glucuronic acid lactone;Glucurone;Glucurolactone;Glucoxy;D-Glucurono-γ-lactone;D-Glucuronic acid lactone |
| CAS号 : | 32449-92-6 | |
| 货号 : | A695148 | |
| 分子式 : | C6H8O6 | |
| 纯度 : | 98% | |
| 分子量 : | 176.124 | |
| MDL号 : | MFCD00135622 | |
| 存储条件： |
粉末 Keep in dark place,Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(596.17 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 50 mg/mL(283.89 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | D-Glucuronic acid lactone is an endogenous metabolite. In the presence of iron salts and hydrogen peroxide, D-glucuronic acid was converted into D-glucaric acid. Microsomal preparations in the presence of NADPH also produced D-glucarate from D-glucuronic acid, presumably due to formation of hydrogen peroxide, and the product was an inhibitor of beta-D-glucuronidase[1]. Amount of D-glucaric acid, L-ascorbic acid, and D-glucuronic acid in urine increased in the case of the alloxan diabetic rabbits. L-Gulonic acid dehydrogenase, lactonase II, and beta-glucuronidase activities were reduced, and UDPGA-pyrophosphatase, D-glucuronic acid-1-phosphatase, and UDPGA-transferase activities increased in the diabetic rabbit liver[2]. Agrobacterium tumefaciens uronate dehydrogenase (AtuUdh) belongs to the short-chain dehydrogenase superfamily, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. It is apparently required for the production of D-glucaric acid. AtuUdh-catalyzed reaction is reversible with dual substrate-specific activity (D-galacturonic acid and D-glucuronic acid) in nature. Q14F, S36L, and S75T mutants have shown a high binding affinity to D-glucuronic acid and its substrate intermediates such as D-glucaro-1,4-lactone and D-glucaro-1,5-lactone. D34S, N112E and S165E mutants found to show a high selectivity of D-galacturonic acid and its substrate intermediates for D-galactaric acid production[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
5.68mL 1.14mL 0.57mL |
28.39mL 5.68mL 2.84mL |
56.78mL 11.36mL 5.68mL |
| 参考文献 |
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