产品说明书

RN486

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Chemical Structure| 1242156-23-5 同义名 : -
CAS号 : 1242156-23-5
货号 : A694095
分子式 : C35H35FN6O3
纯度 : 99%+
分子量 : 606.689
MDL号 : MFCD24682729
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 20 mg/mL(32.97 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • BTK

    BTK, IC50:4 nM
描述 RN486 is a selective Btk inhibitor with an IC50 Value of 4.0 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.65mL

0.33mL

0.16mL

8.24mL

1.65mL

0.82mL

16.48mL

3.30mL

1.65mL
参考文献

[1]Hsu J, Gu Y, et al. Bruton's Tyrosine Kinase mediates platelet receptor-induced generation of microparticles: a potential mechanism for amplification of inflammatory responses in rheumatoid arthritis synovial joints. Immunol Lett. 2013 Feb;150(1-2):97-104.

[2]Xu D, Kim Y, et al. RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents. J Pharmacol Exp Ther. 2012 Apr;341(1):90-103.