产品说明书

Acoziborole

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Chemical Structure| 1266084-51-8 同义名 : SCYX-7158;AN5568;Oxaborole
CAS号 : 1266084-51-8
货号 : A692365
分子式 : C17H14BF4NO3
纯度 : 99%+
分子量 : 367.103
MDL号 : MFCD30532746
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(326.88 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Acoziborole (SCYX-7158) is identified as a potent, safe, and orally administrable antiprotozoal compound, which holds promise for the study and potential treatment of Human African Trypanosomiasis (HAT). Specifically against the Trypanosoma brucei brucei S427 strain, SCYX-7158 exhibits a minimal inhibitory concentration (MIC) value of 0.6 µg/mL, highlighting its effectiveness against this parasitic disease[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.72mL

0.54mL

0.27mL

13.62mL

2.72mL

1.36mL

27.24mL

5.45mL

2.72mL
参考文献

[1]Jacobs RT, et al. SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis. PLoS Negl Trop Dis. 2011 Jun;5(6):e1151.