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Suplatast (Tosilate)

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Chemical Structure| 94055-76-2 同义名 : IPD 1151T;Suplatast tosilate;Suplatast (tosylate);Suplatast Tosylate
CAS号 : 94055-76-2
货号 : A692262
分子式 : C23H33NO7S2
纯度 : 98%
分子量 : 499.641
MDL号 : MFCD00867604
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(70.05 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(200.14 mM)
动物实验配方：
生物活性
描述 Type 2 helper T cells (Th2) are essential for allergen-induced bronchial hyperresponsiveness and eosinophilic inflammation. Suplatast tosilate is an anti-allergic drug that suppresses IgE synthesis in both mice and humans without affecting total IgG and IgM production[3]. Suplatast tosilate at 1–10µg/mL suppresses human IgE synthesis in a concentration-dependent manner. Suplatast tosilate at 10µg/mL reduced the mRNA level of IL-4 in phytohemagglutinin-stimulated human peripheral blood mononuclear cells[4]. In ovalbumin (OVA)-challenged mice, treatment with 100mg/kg suplatast tosilate significantly decreases the number of total cells and eosinophils in bronchoalveolar lavage fluid compared with OVA control mice. Mice treated with suplatast tosilate also show significantly lower levels of IL-4, IL-5, and IL-13 in mice in comparison with the controls[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.00mL

0.40mL

0.20mL

10.01mL

2.00mL

1.00mL

20.01mL

4.00mL

2.00mL
参考文献

[1]Tamaoki J, Kondo M, et al. Effect of suplatast tosilate, a Th2 cytokine inhibitor, on steroid-dependent asthma: a double-blind randomised study. Tokyo Joshi-Idai Asthma Research Group. Lancet. 2000;356(9226):273-8.

[2]Iijima H, Tamura G, et al. Suplatast tosilate inhibits late response and airway inflammation in sensitized guinea pigs. Am J Respir Crit Care Med. 1999;160(1):331-5

[3]Zhao GD, Yokoyama A, Kohno N, Sakai K, Hamada H, Hiwada K. Effect of suplatast tosilate (IPD-1151T) on a mouse model of asthma: inhibition of eosinophilic inflammation and bronchial hyperresponsiveness. Int Arch Allergy Immunol. 2000;121(2):116-122.

[4]Yanagihara Y, Kiniwa M, Ikizawa K, Shida T, Matsuura N, Koda A. Suppression of IgE production by IPD-1151T (suplatast tosilate), a new dimethylsulfonium agent: (2). Regulation of human IgE response. Jpn J Pharmacol. 1993;61(1):31-39.