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Albiflorin

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Chemical Structure| 39011-90-0 同义名 : -
CAS号 : 39011-90-0
货号 : A691747
分子式 : C23H28O11
纯度 : 98%
分子量 : 480.462
MDL号 : MFCD00238531
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(218.54 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(208.13 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 The root of Paeonia lactiflora Pall (family Ranunculaceae) or peony root is a commonly used Chinese herbal medicine in clinical practice. Empirical evidence suggests that various peony root preparations have broad therapeutic benefits for pain, muscle spasm, inflammation, menstrual dysfunction, and neurodegenerative disorder. The isomer albiflorin (AF) is a major constituent contained in peony root. Pretreatment with AF at 50 μM and 100 μM significantly reduced the lethal effect of Glu (P<0.05). Pretreatment with 100 μM AF almost completely inhibited Glu-induced apoptotic alternation, with a >93 % of survival rate compared to 84 % in untreated cells (P<0.05). Moreover, Glu-induced increase of ROS level was suppressed to control level by 100 μM AF pretreatment (P<0.05), suggesting that the protective effect of AF against Glu neurotoxicity are associated with the reduction of intracellular ROS level. In the presence of 100 μM AF, the phosphorylation of AKT and GSK3β was up-regulated in a time-dependent manner (P<0.05) indicating that the activation of AKT/GSK-3β is associated with the protective effects of AF against Glu neurotoxicity[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.08mL

0.42mL

0.21mL

10.41mL

2.08mL

1.04mL

20.81mL

4.16mL

2.08mL
参考文献

[1]Wang QS, Gao T, et al. Comparative studies of paeoniflorin and albiflorin from Paeonia lactiflora on anti-inflammatory activities. Pharm Biol. 2014 Sep;52(9):1189-95.

[2]Sheng Y, Li L, et al. Simultaneous determination of albiflorin and paeoniflorin in rat urine by solid-phase extraction and high-performance liquid chromatography following oral administration of Si-Wu decoction. Biomed Chromatogr. 2004 Dec;18(10):785-90.

[3]Wang D, Tan QR, Zhang ZJ. Neuroprotective effects of paeoniflorin, but not the isomer albiflorin, are associated with the suppression of intracellular calcium and calcium/calmodulin protein kinase II in PC12 cells. J Mol Neurosci. 2013;51(2):581‐590