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(1R,2R)-2-PCCA HCl

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Chemical Structure| 1609563-71-4 同义名 : (1R,2R)-2-PCCA hydrochloride
CAS号 : 1609563-71-4
货号 : A691315
分子式 : C30H39Cl2N3O
纯度 : 97%
分子量 : 528.556
MDL号 : MFCD31657321
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(94.6 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 GPR88 is an orphan G-protein-coupled receptor that plays an essential role in regulating striatal functions. (1R,2R)-2-PCCA 2 is a potent GPR88 agonist that inhibits isoproterenol-induced cAMP formation with an EC50 value of 603nM (pEC50 = 6.22) in cell assay[1]. In CHO cells overexpressing the PPLS-HA-GPR88 construct, the EC50 value of (1R,2R)-2-PCCA 2 is 56nM[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.89mL

0.38mL

0.19mL

9.46mL

1.89mL

0.95mL

18.92mL

3.78mL

1.89mL
参考文献

[1]Jin C, Decker AM, Huang XP, et al. Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor. ACS Chem Neurosci. 2014;5(7):576-587.

[2]Jin C, Decker AM, Harris DL, Blough BE. Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies. ACS Chem Neurosci. 2016;7(10):1418-1432.