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Genz-123346 free base

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Chemical Structure| 491833-30-8 同义名 : Genz-123346
CAS号 : 491833-30-8
货号 : A691149
分子式 : C24H38N2O4
纯度 : 99%
分子量 : 418.57
MDL号 : MFCD22419854
存储条件：

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(250.85 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Genz-123346 free base is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1 and IC50 for GM1 inhibition is 14 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.39mL

0.48mL

0.24mL

11.95mL

2.39mL

1.19mL

23.89mL

4.78mL

2.39mL
参考文献

[1]Chai L, McLaren RP, Byrne A, et al. The chemosensitizing activity of inhibitors of glucosylceramide synthase is mediated primarily through modulation of P-gp function. Int J Oncol. 2011 Mar;38(3):701-11.

[2]Zhao H, Przybylska M, et al. Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes. Diabetes. 2007 May;56(5):1210-8.