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MK-2461

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Chemical Structure| 917879-39-1 同义名 : -
CAS号 : 917879-39-1
货号 : A683250
分子式 : C24H25N5O5S
纯度 : 98%+
分子量 : 495.551
MDL号 : MFCD11977739
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(60.54 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • PDGFRβ

    PDGFRβ, IC50:22 nM

  • FGFR2

    FGFR2, IC50:39 nM

  • FGFR3

    FGFR3, IC50:50 nM

  • FGFR1

    FGFR1, IC50:65 nM
描述 MK-2461 is a potent, multi-targeted inhibitor for c-Met (WT/mutants) with IC50 of 0.4-2.5 nM, less potent to Ron, Flt1 and with 8- to 30-fold greater selectivity of c-Met targets versus FGFR1, FGFR2, FGFR3, PDGFRβ, KDR, Flt3, Flt4, TrkA, and TrkB.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.02mL

0.40mL

0.20mL

10.09mL

2.02mL

1.01mL

20.18mL

4.04mL

2.02mL
参考文献

[1]Pan BS, Chan GK, et al. MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33.

[2]Park YW, Cummings RT, et al. Homogeneous proximity tyrosine kinase assays: scintillation proximity assay versus homogeneous time-resolved fluorescence. Anal Biochem. 1999 Apr 10;269(1):94-104.