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Polyphyllin VI

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Chemical Structure| 55916-51-3 同义名 : 重楼皂苷Ⅵ
CAS号 : 55916-51-3
货号 : A682627
分子式 : C39H62O13
纯度 : 98%
分子量 : 738.902
MDL号 : MFCD13195303
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(142.1 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Polyphyllin VI, a natural product isolated and purified from the rhizomes of Paris yunnanensis Franch. with hemostasis, expectorant, bacteriostasis, anticytotoxic, anti-pregnancy and sperm-killing effects. Polyphyllin VI (PPVI), a main saponin isolated from TTM, significantly suppress the proliferation of non-small cell lung cancer (NSCLC) via the induction of apoptosis and autophagy in vitro and in vivo[3]. Polyphyllin VI could potently inhibit cell proliferation by causing G2/M phase arrest. Polyphyllin VI may effectively induce apoptosis and autophagy to suppress cell growth via ROS/JNK activation in U2OS (human osteosarcoma cells) cells[4]. Furthermore, JNK and p38 inhibitors ameliorated PPVI-triggered autophagy and apoptosis in glioma cells. PPVI inhibited tumor growth of U87 cell line in nude mice[5]. Polyphyllin VI changed cell morphology and induced apoptosis in HepaRG cells. Polyphyllin VI induced cell apoptosis through mitochondrial pathway by the generation of ROS and Fas death-dependent pathway. All of the effects are in dose- and time-dependent manners[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.35mL

0.27mL

0.14mL

6.77mL

1.35mL

0.68mL

13.53mL

2.71mL

1.35mL
参考文献

[1]Zhao Y, Zhang J, et al. Discrimination of wild Paris based on near infrared spectroscopy and high performance liquid chromatography combined with multivariate analysis. PLoS One. 2014 Feb 18;9(2):e89100.

[2]Yin X, Qu C, et al. Simultaneous determination and pharmacokinetic study of polyphyllin I, polyphyllin II, polyphyllin VI and polyphyllin VII in beagle dog plasma after oral administration of Rhizoma Paridis extracts by LC-MS-MS. Biomed Chromatogr. 2013 Mar;27(3):343-8.

[3]Teng JF, Mei QB, Zhou XG, Tang Y, Xiong R, Qiu WQ, Pan R, Law BY, Wong VK, Yu CL, Long HA, Xiao XL, Zhang F, Wu JM, Qin DL, Wu AG. Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer. Cancers (Basel). 2020 Jan 13;12(1):193

[4]Yuan YL, Jiang N, Li ZY, Song ZZ, Yang ZH, Xue WH, Zhang XJ, Du Y. Polyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation. Drug Des Devel Ther. 2019 Aug 28;13:3091-3103

[5]Liu W, Chai Y, Hu L, Wang J, Pan X, Yuan H, Zhao Z, Song Y, Zhang Y. Polyphyllin VI Induces Apoptosis and Autophagy via Reactive Oxygen Species Mediated JNK and P38 Activation in Glioma. Onco Targets Ther. 2020 Mar 13;13:2275-2288

[6]Liu Y, Dong X, Wang W, You L, Yin X, Yang C, Sai N, Leng X, Ni J. Molecular Mechanisms of Apoptosis in HepaRG Cell Line Induced by Polyphyllin VI via the Fas Death Pathway and Mitochondrial-Dependent Pathway. Toxins (Basel). 2018 May 15;10(5):201