Gastrin I, human
产品说明书
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同义名 : | Gastrin I (human);Gastrin Heptadecapeptide I (human);Gastrin I (1-17) (human) |
| CAS号 : | 10047-33-3 | |
| 货号 : | A680549 | |
| 分子式 : | C97H124N20O31S | |
| 纯度 : | 98% | |
| 分子量 : | 2098.203 | |
| MDL号 : | MFCD00076500 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(23.83 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO NH4OH: 50 mg/mL(23.83 mM)，配合低频超声，并调节pH至11 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | The peptide cholecystokinin (CCK), originally discovered in the gastrointestinal tract, has been shown to mediate pancreatic secretion and contraction of gallbladder. Two types of CCK receptors (CCK1 found in the gut and CCK2 found in the brain) have thus been distinguished. Gastrin-1, human, a endogenous peptide produced in the stomach, increases gastric acid secretion via acting at CCK2 receptor[1]. In anaesthetized rats, gastrin-1, human (1.5, 5, 15 and 45 nmol/kg, i.v.) increased both pepsinogen and acid secretion. After pretreatment with omeprazole, gastrin-1, human failed to stimulate acid secretion, while it increased pepsinogen output. In rats with gastric perfusion of acid solutions, gastrin-1, human increased peptic output in a pH-independent manner either with or without pretreatment with omeprazole[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
0.48mL 0.10mL 0.05mL |
2.38mL 0.48mL 0.24mL |
4.77mL 0.95mL 0.48mL |
| 参考文献 |
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