产品说明书

Isotaxiresinol

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Chemical Structure| 26194-57-0 同义名 : -
CAS号 : 26194-57-0
货号 : A677954
分子式 : C19H22O6
纯度 : 98+%
分子量 : 346.37
MDL号 : -
存储条件:

粉末

液体 -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 Isotaxiresinol, a natural product isolated and purified from the branch of Taxus wallichiana, may be useful for treatment of postmenopausal osteoporosis, especially for prevention of bone fracture induced by estrogen deficiency, and prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis induced by TNF-alpha.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.89mL

0.58mL

0.29mL

14.44mL

2.89mL

1.44mL

28.87mL

5.77mL

2.89mL

参考文献

[1]Yin J, Tezuka Y, et al. In vivo anti-osteoporotic activity of isotaxiresinol, a lignan from wood of Taxus yunnanensis. Phytomedicine. 2006 Jan;13(1-2):37-42.

[2]Banskota AH, Nguyen NT, et al. Secoisolariciresinol and isotaxiresinol inhibit tumor necrosis factor-alpha-dependent hepatic apoptosis in mice. Life Sci. 2004 Apr 16;74(22):2781-92.