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6-OAU

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Chemical Structure| 83797-69-7 同义名 : GTPL5846;6-n-octylaminouracil
CAS号 : 83797-69-7
货号 : A677127
分子式 : C12H21N3O2
纯度 : 99%+
分子量 : 239.314
MDL号 : MFCD28900678
存储条件:

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 25 mg/mL(104.47 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 6-OAU (GTPL5846) (6-n-octylaminouracil) functions as a GPR84 (G protein-coupled receptor 84) agonist with an EC50 of 105 nM. It attracts PMNs and macrophages, boosts IL-8 proinflammatory cytokine levels, indicating its proinflammatory effects. Additionally, 6-OAU has antibacterial capabilities[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.18mL

0.84mL

0.42mL

20.89mL

4.18mL

2.09mL

41.79mL

8.36mL

4.18mL

参考文献

[1]Suzuki M, et al. Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem. 2013 Apr 12;288(15):10684-91.

[2]Reyes AWB, et al. Immune-metabolic receptor GPR84 surrogate and endogenous agonists, 6-OAU and lauric acid, alter Brucella abortus 544 infection in both in vitro and in vivo systems. Microb Pathog. 2021 Sep. 158:105079.