Ro 48-8071 fumarate

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Chemical Structure| 189197-69-1 同义名 : -
CAS号 : 189197-69-1
货号 : A674342
分子式 : C27H31BrFNO6
纯度 : 99%+
分子量 : 564.441
MDL号 : MFCD05865242
存储条件：

Pure form Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 55 mg/mL(97.44 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(177.17 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Ro 48-8071 fumarate is an inhibitor of OSC (Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.77mL

0.35mL

0.18mL

8.86mL

1.77mL

0.89mL

17.72mL

3.54mL

1.77mL
参考文献

[1]Shoemaker CJ, Schornberg KL, et al. Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection. PLoS One. 2013;8(2):e56265.

[2]Morand OH, Aebi JD, et al. Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. J Lipid Res. 1997 Feb;38(2):373-90.