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CPHPC(Miridesap)

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Chemical Structure| 224624-80-0 同义名 : "CPHPC;Ro63-8695;CPOHPC acid;GSK2315698；CPHPC；CPOHPC （acid form;Ro638695；GSK-2315698;Ro-638695；
CAS号 : 224624-80-0
货号 : A674278
分子式 : C16H24N2O6
纯度 : 97%
分子量 : 340.372
MDL号 : MFCD09970762
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 80 mg/mL(235.04 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 10 mg/mL(29.38 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Miridesap is an antineoplastic which depletes circulating serum amyloid P component (SAP) almost completely but leaves some SAP in amyloid deposits for specific recognition by subsequently administered therapeutic anti-SAP antibodies.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.94mL

0.59mL

0.29mL

14.69mL

2.94mL

1.47mL

29.38mL

5.88mL

2.94mL
参考文献

[1]Al-Shawi R, Tennent GA, et al. Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits in vivo. Open Biol. 2016 Feb;6(2):150202.

[2]Richards DB, Cookson LM, et al. Therapeutic Clearance of Amyloid by Antibodies to Serum Amyloid P Component. N Engl J Med. 2015 Sep 17;373(12):1106-14.