Raf inhibitor 1 2HCl
产品说明书
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同义名 : | B-Raf inhibitor 1 dihydrochloride;B-RAF Inhibitor 1 (hydrochloride);Raf inhibitor 1 dihydrochloride |
| CAS号 : | 1191385-19-9 | |
| 货号 : | A674211 | |
| 分子式 : | C26H21Cl3N8 | |
| 纯度 : | 99%+ | |
| 分子量 : | 551.857 | |
| MDL号 : | MFCD18782676 | |
| 存储条件： |
Pure form Inert atmosphere,Room Temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | B-Raf inhibitor 1 curtails proliferation in A375 and HCT-116 cells with IC50s of 0.31 μM and 0.72 μM, respectively. This inhibitor also connects to and maintains B-Raf in a DFG-out inactive configuration where the ATP pocket is partially occupied by Phe595 and Gly596 of the DFG motif. Moreover, B-Raf inhibitor 1 demonstrates inhibition at low micromolar concentrations in wild type B-Raf cell lines, possibly from unintended kinase effects or widespread Raf inhibition, including interactions between Raf dimers[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.81mL 0.36mL 0.18mL |
9.06mL 1.81mL 0.91mL |
18.12mL 3.62mL 1.81mL |
| 参考文献 |
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