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Ramosetron HCl

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Chemical Structure| 132907-72-3 同义名 : YM060;Ramosetron (hydrochloride);Ramosetron Hydrochloride
CAS号 : 132907-72-3
货号 : A671888
分子式 : C17H18ClN3O
纯度 : 98%
分子量 : 315.797
MDL号 : MFCD00894748
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(95 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(316.66 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • 5-HT3

    5-HT3 receptor, Ki:0.091 nM
描述 Ramosetron Hydrochloride, a selective 5-HT3 receptor antagonist, has been on the market as an antiemetic drug for cancer patients receiving chemotherapy or anesthesia. The effective dose of ramosetron (hydrochlorid) to be injected for the near-complete prophylaxis of PONV (Postoperative nausea and vomiting) 6 to 24 hours after surgery in high-risk patients is a 0.6 mg bolus injection at the end of the surgery[2]. Moreover, ramosetron (hydrochlorid) administered during induction of anaesthesia may affect maximal change in QTc interval during off-pump coronary artery bypass surgery[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.17mL

0.63mL

0.32mL

15.83mL

3.17mL

1.58mL

31.67mL

6.33mL

3.17mL
参考文献

[1]Yahagi R, Machida Y, Onishi H. Mucoadhesive suppositories of ramosetron hydrochloride utilizing Carbopol. Int J Pharm. 2000 Jan 5;193(2):205-12.

[2]Lee S, Jeong S, Kim J, Jeong S. Effective Dose of Ramosetron for Prophylaxis of Postoperative Nausea and Vomiting in High-Risk Patients. Biomed Res Int. 2015;2015:951474. doi: 10.1155/2015/951474. Epub 2015 Jul 14. PMID: 26258145; PMCID: PMC4516817.

[3]Kim TK, Cho YJ, Lim CW, Min JJ, Choi EK, Hong DM, Jeon Y. Effect of ramosetron on QTc interval: a randomised controlled trial in patients undergoing off-pump coronary artery bypass surgery. BMC Anesthesiol. 2016 Aug 3;16(1):56. doi: 10.1186/s12871-016-0222-1. PMID: 27488394; PMCID: PMC4972982.