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Ki16198

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Chemical Structure| 355025-13-7 同义名 : -
CAS号 : 355025-13-7
货号 : A666171
分子式 : C24H25ClN2O5S
纯度 : 99%+
分子量 : 488.984
MDL号 : MFCD23704182
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(214.73 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • LPA1

    LPA1, Ki:0.34 μM

  • LPA3

    LPA3, Ki:0.93 μM
描述 Ki16198 is a potent and orally active antagonist of LPA receptors, functioning as the methyl ester derivative of Ki16425. It demonstrates efficacy in inhibiting LPA1 and LPA3-induced inositol phosphate production, with Ki values of 0.34 μM and 0.93 μM, respectively, showcasing its potential against pancreatic cancer tumorigenesis and metastasis when applied in vivo[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.05mL

0.41mL

0.20mL

10.23mL

2.05mL

1.02mL

20.45mL

4.09mL

2.05mL
参考文献

[1]Mayumi Komachi, et al. Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo. Cancer Sci. 2012 Jun;103(6):1099-104.