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(-)-Epiafzelechin

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Chemical Structure| 24808-04-6 同义名 : (-)-表阿夫儿茶精
CAS号 : 24808-04-6
货号 : A665855
分子式 : C15H14O5
纯度 : 98+%
分子量 : 274.27
MDL号 : MFCD20260428
存储条件:

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 50 mg/mL(182.3 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 (-)-Epiafzelechin, a natural product isolated and purified from the herbs of Celastrus orbiculatus with antioxidant activity, exhibits various modes of action in suppressing HSV-2 multiplication, a dose-dependent inhibition on the COX activity with an IC50 value of 15 µM, and significant anti-inflammatory activity on carrageenin-induced mouse paw edema when the compound (100 mg/kg) was orally administrated at 1 h before carrageenin treatment.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.65mL

0.73mL

0.36mL

18.23mL

3.65mL

1.82mL

36.46mL

7.29mL

3.65mL

参考文献

[1]Wong KC, Law MC, et al. Development of a UPLC-MS/MS bioanalytical method for the pharmacokinetic study of (-)-epiafzelechin, a flavan-3-ol with osteoprotective activity, in C57BL/6J mice. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Sep 15;967:162-7.

[2]Min KR, Hwang BY, et al. (-)-Epiafzelechin: cyclooxygenase-1 inhibitor and anti-inflammatory agent from aerial parts of Celastrus orbiculatus. Planta Med. 1999 Jun;65(5):460-2.