产品说明书

Oleandrin

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Chemical Structure| 465-16-7 同义名 : PBI-05204;Folinerin;Neriol;Corrigen;Neriostene;Neriolin;Foliandrin
CAS号 : 465-16-7
货号 : A664544
分子式 : C32H48O9
纯度 : 98+%
分子量 : 576.718
MDL号 : MFCD00079204
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(182.06 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Oleandrin, a natural product isolated and purified from the herbs of Nerium oleander L., inhibits the activity of NF-κB in various cultured cell lines (U937, CaOV3, human epithelial cells and T cells) as well as it induces programmed cell death in PC3 cell line culture.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.73mL

0.35mL

0.17mL

8.67mL

1.73mL

0.87mL

17.34mL

3.47mL

1.73mL
参考文献

[1]Raviprakash N, Manna SK. Short-term exposure to oleandrin enhances responses to IL-8 by increasing cell surface IL-8 receptors. Br J Pharmacol. 2014 Jul;171(14):3339-51.

[2]Yang P, Menter DG, et al. Oleandrin-mediated inhibition of human tumor cell proliferation: importance of Na,K-ATPase alpha subunits as drug targets. Mol Cancer Ther. 2009 Aug;8(8):2319-28.