Penicillin G potassium

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Chemical Structure| 113-98-4 同义名 : 青霉素钾 ;Benzylpenicillin potassium;Penicillin G (potassium salt);NSC 131815;Benzylpenicillin
CAS号 : 113-98-4
货号 : A664318
分子式 : C16H17KN2O4S
纯度 : 98%
分子量 : 372.481
MDL号 : -
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 100 mg/mL(268.47 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Penicillin G potassium is a fast-acting antibiotic, used to treat bacterial infections that affect the blood, heart, lungs, joints, and genital areas. Penicillin G potassium troches are effective in reducing ulcer size and alleviating ulcer pain of the patients in the treatment of a single episode of MiRAU (minor recurrent aphthous ulcerations) in this Chinese cohort[3]. Potassium penicillin G administered in drinking water is effective in reducing mortality associated with S. suis infection and reducing tonsillar carriage of S. suis[4]. IV administration of Penicillin G Potassium stimulates defecation and myoelectric activity of the cecum and pelvic flexure in horses. Effects of Penicillin G Potassium may be beneficial during episodes of ileus[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01975493 - Active, not recruiting June 2018 United Kingdom ... 展开 >> Royal Cornwall Hospitals NHS Trust Truro, Cornwall, United Kingdom, TR1 3LJ Taunton and Somerset NHS Foundation Trust Taunton, Somerset, United Kingdom, TA1 5DA University Hospitals Coventry and Warwickshire NHS Trust Coventry, United Kingdom, CV2 2DX Alder Hey Children's Hospital Liverpool, United Kingdom, L12 2AP Liverpool Women's Hospital Liverpool, United Kingdom, L8 7SS St George's Hospital London, United Kingdom, SW17 0QT Great Ormond Street Hospital London, United Kingdom, WC1N 3JH John Radcliffe Hospital Oxford, United Kingdom, OX3 9DU Queen Alexandra Hospital Portsmouth, United Kingdom, PO6 3LY 收起 <<
NCT02171338 Pneumonia Acu... 展开 >>te Exacerbation of Chronic Obstructive Airways Disease 收起 << Phase 4 Unknown September 2014 Denmark ... 展开 >> Holbæk Hospital Holbæk, Denmark, 4300 收起 <<
NCT01818336 - Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.68mL

0.54mL

0.27mL

13.42mL

2.68mL

1.34mL

26.85mL

5.37mL

2.68mL
参考文献

[1]Byra C, Gadbois P, et al. Decreased mortality of weaned pigs with Streptococcus suis with the use of in-water potassium penicillin G. Can Vet J. 2011 Mar;52(3):272-6.

[2]Roussel AJ, Hooper RN, et al. Evaluation of the effects of penicillin G potassium and potassium chloride on the motility of the large intestine in horses. Am J Vet Res. 2003 Nov;64(11):1360-3.

[3]Zhou Y, Chen Q, Meng W, Jiang L, Wang Z, Liu J, Lin M, Zhou H, Chen X, Zhao M, Zeng X. Evaluation of penicillin G potassium troches in the treatment of minor recurrent aphthous ulceration in a Chinese cohort: a randomized, double-blinded, placebo and no-treatment-controlled, multicenter clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Apr;109(4):561-6. doi: 10.1016/j.tripleo.2009.11.006. Epub 2010 Feb 26. PMID: 20188604.

[4]Byra C, Gadbois P, Cox WR, Gottschalk M, Farzan V, Bauer SA, Wilson JB. Decreased mortality of weaned pigs with Streptococcus suis with the use of in-water potassium penicillin G. Can Vet J. 2011 Mar;52(3):272-6. PMID: 21629419; PMCID: PMC3039896.

[5]Roussel AJ, Hooper RN, Cohen ND, Bye AD, Hicks RJ, Schulze JL. Evaluation of the effects of penicillin G potassium and potassium chloride on the motility of the large intestine in horses. Am J Vet Res. 2003 Nov;64(11):1360-3. doi: 10.2460/ajvr.2003.64.1360. PMID: 14620770.