产品说明书

Norathyriol

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Chemical Structure| 3542-72-1 同义名 : Mangiferitin
CAS号 : 3542-72-1
货号 : A663218
分子式 : C13H8O6
纯度 : 98%
分子量 : 260.199
MDL号 : MFCD13689186
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(403.54 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Norathyriol, a natural product isolated and purified from the herbs of Mangifera indica L., can improve the glucose utilization and insulin sensitivity by up-regulation of the phosphorylation of AMPK. Norathyriol exerts a potent chemopreventive activity by inhibiting Akt activation in neoplastic cell transformation.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.84mL

0.77mL

0.38mL

19.22mL

3.84mL

1.92mL

38.43mL

7.69mL

3.84mL
参考文献

[1]Ding H, Zhang Y, et al. Norathyriol reverses obesity- and high-fat-diet-induced insulin resistance in mice through inhibition of PTP1B. Diabetologia. 2014 Oct;57(10):2145-54.

[2]Wang F, Yan J, et al. Mangiferin and its aglycone, norathyriol, improve glucose metabolism by activation of AMP-activated protein kinase. Pharm Biol. 2014 Jan;52(1):68-73.