BNC105

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Chemical Structure| 945771-74-4 同义名 : -
CAS号 : 945771-74-4
货号 : A648997
分子式 : C20H20O7
纯度 : 98%+
分子量 : 372.369
MDL号 : MFCD22628798
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(67.14 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.69mL

0.54mL

0.27mL

13.43mL

2.69mL

1.34mL

26.86mL

5.37mL

2.69mL
参考文献

[1]Bates D, Feris EJ, et al. Rapid induction of apoptosis in chronic lymphocytic leukemia cells by the microtubule disrupting agent BNC105. Cancer Biol Ther. 2016;17(3):291-9.

[2]Kremmidiotis G, Leske AF, et al. BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy. Mol Cancer Ther. 2010 Jun;9(6):1562-73.