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kb NB 142-70

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Chemical Structure| 1233533-04-4 同义名 : -
CAS号 : 1233533-04-4
货号 : A648803
分子式 : C11H9NO2S2
纯度 : 98%
分子量 : 251.325
MDL号 : MFCD18086915
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 45 mg/mL(179.05 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 kb NB 142-70 is a selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.98mL

0.80mL

0.40mL

19.89mL

3.98mL

1.99mL

39.79mL

7.96mL

3.98mL
参考文献

[1]Guo J, Clausen DM, et al. In vitro cytotoxicity, pharmacokinetics, tissue distribution, and metabolism of small-molecule protein kinase D inhibitors, kb-NB142-70 and kb-NB165-09, in mice bearing human cancer xenografts. Cancer Chemother Pharmacol. 2013 Feb;71(2):331-44.

[2]Bravo-Altamirano K, George KM, et al. Synthesis and Structure-Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D. ACS Med Chem Lett. 2011 Feb 14;2(2):154-159.