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Perhexiline maleate

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Chemical Structure| 6724-53-4 同义名 : 哌克昔林 马来酸盐 ;Perhexiline (maleate)
CAS号 : 6724-53-4
货号 : A645812
分子式 : C23H39NO4
纯度 : 99%+
分子量 : 393.56
MDL号 : MFCD00057329
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 3 mg/mL(7.62 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 25 mg/mL(63.52 mM)，配合低频超声，并水浴加热至45℃助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：
生物活性
描述 Perhexiline maleate, an orally active inhibitor of CPT1 and CPT2, curtails fatty acid metabolism and induces mitochondrial dysfunction and apoptosis in hepatic cells. It can cross the blood-brain barrier (BBB) and exhibits anti-tumor properties. Perhexiline maleate is researched for its potential therapeutic applications in cancer and cardiovascular diseases such as angina[1].[2].[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02431221 Hypertrophic Cardiomyopathy Phase 3 Withdrawn(Lack of efficacy in ... 展开 >>a preceding study.) 收起 << - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.54mL

0.51mL

0.25mL

12.70mL

2.54mL

1.27mL

25.41mL

5.08mL

2.54mL
参考文献

[1]E. Marc Jolicoeur, et al. 27 - Refractory Angina. Chronic Coronary Artery Disease, 2018, 412-431.

[2]Zhen Ren, et al. Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline. Toxicol In Vitro. 2020 Dec;69:104987.

[3]P-P Liu, et al. Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline. Oncogene. 2016 Oct 27;35(43):5663-5673.

[4]Giovanni Licari, et al. Enantioselectivity in the tissue distribution of perhexiline contributes to different effects on hepatic histology and peripheral neural function in rats. Pharmacol Res Perspect. 2018 Jun;6(3):e00406.

[5]Shiva Kant, et al. Perhexiline Demonstrates FYN-mediated Antitumor Activity in Glioblastoma. Mol Cancer Ther. 2020 Jul;19(7):1415-1422.