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IM-54

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Chemical Structure| 861891-50-1 同义名 : -
CAS号 : 861891-50-1
货号 : A644858
分子式 : C19H23N3O2
纯度 : 99%+
分子量 : 325.405
MDL号 : MFCD18382109
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(153.65 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 IM-54 is a selective inhibitor of oxidative stress-induced necrosis. IM-54 exhibits potent inhibitory activity against H2O2-induced necrosis. IM-54 is a potential cardioprotective agent and a biological tool for the study of the molecular mechanisms of cell death[1][2].IM-54 selectively inhibits oxidative stress-induced cell necrosis, but not apoptosis or necrosis induced by various anticancer drugs or Fas ligands. IM-54 has a potent inhibitory effect on H2O2-induced necroptosis, with an IC50 of 0.25 μM in HL-60 cells[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.07mL

0.61mL

0.31mL

15.37mL

3.07mL

1.54mL

30.73mL

6.15mL

3.07mL
参考文献

[1]Kosuke Dodo, et al. Indolylmaleimide Derivative IM-17 Shows Cardioprotective Effects in Ischemia-Reperfusion Injury. ACS Med Chem Lett. 2018 Mar 8; 9(3): 182-187.

[2]Mikiko Sodeoka, et al. Development of selective inhibitors of necrosis. Chem Rec. 2010 Oct;10(5):308-14.