产品说明书
Daurisoline
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同义名 : | (R,R)-Daurisoline;(–)-Daurisoline;(–)-Daurisoline, (R,R)-Daurisoline |
| CAS号 : | 70553-76-3 | |
| 货号 : | A639836 | |
| 分子式 : | C37H42N2O6 | |
| 纯度 : | 99+% | |
| 分子量 : | 610.739 | |
| MDL号 : | MFCD00221740 | |
| 存储条件： |
粉末 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(171.92 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Daurisoline, a natural product isolated and purified from the roots of Menispermum dauricu with antiarrhythmic effects, exerts a blocking effect on hERG at concentrations below 30 uM, but does not affect the expression and function of the hERG channel. Daurisoline can inhibit early afterdepolarizations (EADs) which may be associated with its blockade effects on I(Ca-L), shows cytoprotective effects on ischemic injury in cultured pheochromocytoma (PC12) cells, which are mediated by blocking Ca2+ influx into cells, and inhibits the delayed afterdepolarization and triggered activity by preventing an increase of alpha Cai via transmembrane Ca2+ entry and Ca2+ release from the reticulum. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.64mL 0.33mL 0.16mL |
8.19mL 1.64mL 0.82mL |
16.37mL 3.27mL 1.64mL |
| 参考文献 |
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