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Flavokawain A

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Chemical Structure| 3420-72-2 同义名 : 2'-羟基-4,4',6'-三甲氧基查耳酮
CAS号 : 3420-72-2
货号 : A639630
分子式 : C18H18O5
纯度 : 98%
分子量 : 314.332
MDL号 : MFCD00017174
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(334.04 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Flavokawain A, a natural product isolated and purified from the roots of Piper methysticum with anti-tumor and anti-inflammatory activities, can significantly reduce the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and cause cyclin B1 protein accumulation leading to CDK1 activation in T24 cells.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.18mL

0.64mL

0.32mL

15.91mL

3.18mL

1.59mL

31.81mL

6.36mL

3.18mL
参考文献

[1]Abu N, Akhtar MN, et al. Flavokawain A induces apoptosis in MCF-7 and MDA-MB231 and inhibits the metastatic process in vitro. PLoS One. 2014 Oct 6;9(10):e105244.

[2]Kwon DJ, Ju SM, et al. Suppression of iNOS and COX-2 expression by flavokawain A via blockade of NF-κB and AP-1 activation in RAW 264.7 macrophages. Food Chem Toxicol. 2013 Aug;58:479-86.