Balsalazide sodium hydrate
产品说明书
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同义名 : | 巴柳氮钠 ;Balsalazide disodium dihydrate; Balsalazide disodium |
| CAS号 : | 150399-21-6 | |
| 货号 : | A639284 | |
| 分子式 : | C17H17N3Na2O8 | |
| 纯度 : | 99%+ | |
| 分子量 : | 437.312 | |
| MDL号 : | MFCD01631117 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 120 mg/mL(274.4 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 100 mg/mL(228.67 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Balsalazide disodium (BSZ) is a colon-specific prodrug of the salicylate, 5-aminosalicylic acid[3]. It has a variety of biological activities including promoting apoptosis, anti‐inflammatory, and anti‐tumor effects[4]. ¬¬¬A preliminary mechanistic study in cultured human colon cancer cells showed that BSZ inhibited colon cancer cell proliferation in vitro[3]. In the murine azoxymethane (AOM)/dextran sodium sulfate (DSS) model, the number of F4/80-positive macrophages was significantly lower in the BSZ-treated groups compared with the CAC (colitis-associated carcinogenesis) group (P < 0.05). At the endpoint, the total numbers of tumors in the BSZ-treated groups were significantly low compared with the CAC group (P < 0.05), and the BSZ-treated groups had significantly lower F4/80-positive macrophages in the tumor stroma (P < 0.01). The protein production of macrophage inflammatory protein 1β, monocyte chemoattractant protein-1, interleukin (IL)-6, and IL-10 in the colon tissues decreased in concordance with the plasma concentrations of the cytokines (P < 0.05). The BSZ-treated groups revealed lower expression of p-STAT3 compared with the CAC group. These results revealed that BSZ have chemopreventive effects against CAC through IL-6/STAT3 suppression[4]. BSZ treatment of AOM-injected rats reduced ACF (aberrant crypt foci) formation in a dose-dependent manner by 60% with the greatest effect observed on ACF with 4 or more crypts. In B6-Min/+ mice, a dose-dependent reduction of intestinal tumor number was observed which reached 80% in the distal small intestine and colon[3]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.29mL 0.46mL 0.23mL |
11.43mL 2.29mL 1.14mL |
22.87mL 4.57mL 2.29mL |
| 参考文献 |
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