产品说明书
Oxythiamine chloride hydrochloride
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同义名 : | Hydroxythiamine chloride hydrochloride;Oxythiamine (chloride hydrochloride) |
| CAS号 : | 614-05-1 | |
| 货号 : | A638628 | |
| 分子式 : | C12H17Cl2N3O2S | |
| 纯度 : | 98% | |
| 分子量 : | 338.253 | |
| MDL号 : | MFCD00050656 | |
| 存储条件： |
粉末 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(147.82 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Oxythiamine (OT), an analogue of anti-metabolite, is an inhibitor of transketolase, and a thiamine antagonist. Oxythiamine can suppress the nonoxidative synthesis of ribose and induce cell apoptosis by causing a G1 phase arrest in vitro and in vivo. It altered dynamics of protein signals by suppressing phosphor kinase expression in a concentration (0μM, 5μM, 50μM and 500μM)-dependent and time (0h, 12h and 48h)-dependent manner in MIA PaCa-2 cells. A time-dependent, but not dose-dependent, down-regulation of Annexin A1 expression was observed. The inhibition of transketolase by Oxythiamine resulted in changes of multiple cellular signaling pathways associated with cell apoptosis. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.96mL 0.59mL 0.30mL |
14.78mL 2.96mL 1.48mL |
29.56mL 5.91mL 2.96mL |
| 参考文献 |
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