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all-trans-4-Oxoretinoic acid

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Chemical Structure| 38030-57-8 同义名 : all-trans 4-Keto Retinoic Acid;4-oxo Retinoic Acid;4-oxo RA;4-keto atRA;all-trans-4-oxo RA
CAS号 : 38030-57-8
货号 : A637814
分子式 : C20H26O3
纯度 : 95%
分子量 : 314.419
MDL号 : MFCD00870472
存储条件：

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(159.02 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 all-trans-4-Oxoretinoic acid is the active metabolite of vitamin A and induces gene transcription by binding to nuclear retinoic acid receptors (RARs)[1].All-trans-4-Oxoretinoic acid is a biologically active geometric isomer of retinoic acid[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.18mL

0.64mL

0.32mL

15.90mL

3.18mL

1.59mL

31.80mL

6.36mL

3.18mL
参考文献

[1]Topletz AR, et al. Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids. Mol Pharmacol. 2015;87(3):430-41.

[2]Stahl W, et al. 4-oxo-retinoic acid is generated from its precursor canthaxanthin and enhances gap junctional communication in 10T1/2 cells. Adv Exp Med Biol. 1996;387:121-8.