产品说明书

Kobe2602

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Chemical Structure| 454453-49-7 同义名 : -
CAS号 : 454453-49-7
货号 : A635124
分子式 : C14H9F4N5O4S
纯度 : 98%
分子量 : 419.311
MDL号 : MFCD04109605
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 190 mg/mL(453.12 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Kobe2602 is an inhibitor of the Ras-Raf interaction, preventing the binding of H-Ras·GTP to the c-Raf-1 RBD with a Ki of 149 μM and demonstrating antitumor activity[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.38mL

0.48mL

0.24mL

11.92mL

2.38mL

1.19mL

23.85mL

4.77mL

2.38mL
参考文献

[1]Shima, Fumi, et al. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proceedings of the National Academy of Sciences of the United States of America (2013), 110(20), 8182-8187,