产品说明书
Ginsenoside Rh2
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同义名 : | 人参皂苷 Rh2;20(S)-人参皂苷RH2;人参皂甙 Rh2 ;20(S)-Ginsenoside Rh2;20(S)-Rh2;AR1A4936;HYN0605 AR-1A4936;HY-N0605;20S-Ginsenoside Rh2 |
| CAS号 : | 78214-33-2 | |
| 货号 : | A632458 | |
| 分子式 : | C36H62O8 | |
| 纯度 : | 98% | |
| 分子量 : | 622.873 | |
| MDL号 : | MFCD00800712 | |
| 存储条件： |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(80.27 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Caspases are key mediators of apoptosis. Caspase-8 mediates extrinsic, and caspase-9 initiates the intrinsic pathway of apoptosis[3]. Ginsenoside Rh2 (G-Rh2), isolated from the root of Ginseng, is an activator of caspase-8 and caspase-9 and induces cancer cell apoptosis in a multi-path manner. The cell viability of the human tumor cell lines HeLa, SK-HEP-1, SW480, and PC-3 was remarkably inhibited by G-Rh2, with IC50s of 2.52, 3.15, 4.06 and 7.85 μg/mL, respectively. G-Rh2 might have the unique ability to simultaneously and independently activate both caspase-8 and caspase-9 in HeLa cells. In HeLa cells treated with 7.5 μg/mL G-Rh2 for 4 h, Fas (key factor for caspase-8 activation) and TNF-R1 were remarkably up-regulated by G-Rh2 in a time-dependent manner. Furthermore, significant increases in Fas expression and caspase-8 activity following G-Rh2 treatment coincided with an increase in p53 expression in p53-non-mutated HeLa and SK-HEP-1 cells indicating that G-Rh2 may act as a stabilizer for p53[4]. In male C57BL6 mice, the tumor sizes in the G-L group and G-H group (G-L and G-H refer to a low or high dose of G-Rh2 injection) were reduced compared with the tumor group. Moreover, the G-Rh2 treated mice survived longer than the untreated ones in a dose-dependent manner[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.61mL 0.32mL 0.16mL |
8.03mL 1.61mL 0.80mL |
16.05mL 3.21mL 1.61mL |
| 参考文献 |
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