Estrone

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Chemical Structure| 53-16-7 同义名 : 雌酮 ;E1;Oestrone;Estrone (CRM)
CAS号 : 53-16-7
货号 : A632072
分子式 : C18H22O2
纯度 : 98%
分子量 : 270.366
MDL号 : MFCD00003620
存储条件：

Pure form Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(92.47 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • Estrogen receptor
描述 Estrogens are well known as the most important and ubiquitous steroid hormones in the female body and are responsible for sexual and reproductive development1. There are three major forms of estrogen (estrone (E1), estradiol (E2) and estriol (E3)) that occur naturally in women. Estrone (E1), which is predominantly found in postmenopausal women, is produced by the conversion of androstenedione via the enzyme aromatase2[3]. The levels of circulating estrogens, including estrone (E1) and estrone sulfate, are positively associated with the development and growth of breast cancer in postmenopausal females. Breast cancer risk increased with increasing body mass index (BMI) (P(trend) =0.002), and this increase in relative risk (RR) was substantially reduced by adjustment for serum estrogen concentrations. Adjusting for free estradiol reduced the RR for breast cancer associated with a 5 kg/m2 increase in BMI from 1.19 (95% CI = 1.05 to 1.34) to 1.02 (95% CI = 0.89 to 1.17). The increased risk was also significantly decreased after adjusting for other estrogens, including total estradiol, non-sex hormone-binding globulin-bound estradiol, estrone, and estrone sulfate[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.70mL

0.74mL

0.37mL

18.49mL

3.70mL

1.85mL

36.99mL

7.40mL

3.70mL
参考文献

[1]Hoffmann B, Bernhardt AW, et al. [Profiles of estrone, estrone sulfate and progesterone in donkey (Equus asinus) mares during pregnancy] . Tierarztl Prax Ausg G Grosstiere Nutztiere. 2014;42(1):32-9. German.

[2]Oneson IB, Cohen SL. The nature of the conjugated estrone in human pregnancy urine. Endocrinology. 1952 Sep;51(3):173-82.

[3]Kim KJ, Kim HJ, Park HG, Hwang CH, Sung C, Jang KS, Park SH, Kim BG, Lee YK, Yang YH, Jeong JH, Kim YG. A MALDI-MS-based quantitative analytical method for endogenous estrone in human breast cancer cells. Sci Rep. 2016 Apr 19;6:24489. doi: 10.1038/srep24489. PMID: 27091422; PMCID: PMC4836303.

[4]Key TJ, Appleby PN, Reeves GK, Roddam A, Dorgan JF, Longcope C, Stanczyk FZ, Stephenson HE Jr, Falk RT, Miller R, Schatzkin A, Allen DS, Fentiman IS, Key TJ, Wang DY, Dowsett M, Thomas HV, Hankinson SE, Toniolo P, Akhmedkhanov A, Koenig K, Shore RE, Zeleniuch-Jacquotte A, Berrino F, Muti P, Micheli A, Krogh V, Sieri S, Pala V, Venturelli E, Secreto G, Barrett-Connor E, Laughlin GA, Kabuto M, Akiba S, Stevens RG, Neriishi K, Land CE, Cauley JA, Kuller LH, Cummings SR, Helzlsouer KJ, Alberg AJ, Bush TL, Comstock GW, Gordon GB, Miller SR, Longcope C; Endogenous Hormones Breast Cancer Collaborative Group. Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst. 2003 Aug 20;95(16):1218-26. doi: 10.1093/jnci/djg022. PMID: 12928347.