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DC-Chol HCl

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Chemical Structure| 166023-21-8 同义名 : DC-Cholesterol hydrochloride;DC-Chol (hydrochloride);DC-Chol;​Cholesteryl 3β-N-(dimethylaminoethyl)carbamate;DC-Chol hydrochloride
CAS号 : 166023-21-8
货号 : A631552
分子式 : C32H57ClN2O2
纯度 : 99%+
分子量 : 537.26
MDL号 : MFCD28143568
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

无水乙醇: 25 mg/mL(46.53 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：
生物活性
描述 Under appropriate experimental conditions, DC-Chol hydrochloride can inhibit Aβ40 fibril formation. Additionally, DC-Chol hydrochloride strongly suppresses the amyloidogenesis of oxidized hCT in a dose-dependent manner [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.86mL

0.37mL

0.19mL

9.31mL

1.86mL

0.93mL

18.61mL

3.72mL

1.86mL
参考文献

[1]Esmail A Elbassal, et al. Effects of Charged Cholesterol Derivatives on Aβ40 Amyloid Formation. J Phys Chem B. 2016 Jan 14;120(1):59-68.

[2]Richard Lantz, et al. Effects of disulfide bond and cholesterol derivatives on human calcitonin amyloid formation. Biopolymers. 2020 May;111(5):e23343.