产品说明书

Cintirorgon

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Chemical Structure| 2055536-64-4 同义名 : Lyc-55716
CAS号 : 2055536-64-4
货号 : A627902
分子式 : C27H23F6NO6S
纯度 : 99%+
分子量 : 603.53
MDL号 : MFCD31544352
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 110 mg/mL(182.26 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 100 mg/mL(165.69 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：
生物活性
描述 Cintirorgon, also known as LYC-55716, is a first-in-class selective oral bioactive RORγ agonist. Cintirorgon modulates gene expression in RORγ-expressing T-lymphocyte immune cells, resulting in enhanced effector function, decreased immunosuppression, reduced tumour growth, and improved survival[1][2].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03396497 Non-small Cell Lung Cancer Phase 1 Recruiting March 2019 United States, Colorado ... 展开 >> Lycera Investigational Site Recruiting Aurora, Colorado, United States, 80045 United States, Michigan Lycera Investigational Site Recruiting Ann Arbor, Michigan, United States, 48109 United States, Tennessee Lycera Investigational Site Recruiting Nashville, Tennessee, United States, 37203 United States, Washington Lycera Investigational Site Recruiting Seattle, Washington, United States, 98109 收起 <<
NCT02929862 Cancer Phase 1 Phase 2 Recruiting March 2019 -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.66mL

0.33mL

0.17mL

8.28mL

1.66mL

0.83mL

16.57mL

3.31mL

1.66mL