产品说明书
H-α-Me-Tyr-OH
 |
同义名 : | alpha-甲基-L-酪氨酸 ;α-Methyl-L-p-tyrosine;α-Methyltyrosine;L-α-MT;MK-781 |
| CAS号 : | 672-87-7 | |
| 货号 : | A624425 | |
| 分子式 : | C10H13NO3 | |
| 纯度 : | 95% | |
| 分子量 : | 195.215 | |
| MDL号 : | MFCD00064201 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
H2O: 5 mg/mL(25.61 mM)，配合低频超声，水浴加热至45℃，并调节pH至2 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. All of the doses used (50, 100 and 200 mg/kg), metyrosine had significant anti-ulcerative effects in both indomethacin and ethanol-induced ulcer tests. Metyrosine doses of 100 and 200 mg/kg (especially the 200 mg/kg dose) also inhibited carrageenan-induced paw inflammation even more effectively than indomethacin. All doses of metyrosine significantly inhibited high COX-2 activity[3]. Metyrosine prevented ketamine cardiotoxicity in groups A, B and C and metoprolol prevented it in only group C[4]. Metyrosine reduces the epinephrine levels without affecting the corticosterone levels, thereby creating an analgesic effect. Similarly, the combined use of prednisolone and metyrosine provided a stronger analgesic effect than that rendered by metyrosine alone[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
5.12mL 1.02mL 0.51mL |
25.61mL 5.12mL 2.56mL |
51.23mL 10.25mL 5.12mL |
| 参考文献 |
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