NNC 55-0396

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Chemical Structure| 357400-13-6 同义名 : NNC 55-0396 dihydrochloride
CAS号 : 357400-13-6
货号 : A623214
分子式 : C30H40Cl2FN3O2
纯度 : 99%+
分子量 : 564.562
MDL号 : MFCD11878627
存储条件：

Pure form Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(185.98 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 NNC 55-0396 is a highly selective T-type calcium channel blocker, notably effective at an IC50 of 6.8 μM against Cav3.1 T-type channels, making it relevant for neurological disease research[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.77mL

0.35mL

0.18mL

8.86mL

1.77mL

0.89mL

17.71mL

3.54mL

1.77mL
参考文献

[1]Arnulfo Quesadaa, Peter H. Bui, Gregg E. Homanics，et al. Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor. European Journal of Pharmacology. 2011,659 (1): 30-36.

[2]Hideto Miwa, Jinsoo Koh, Yoshinori Kajimoto, et al. Effects of T-type calcium channel blockers on a parkinsonian tremor model in rats. Pharmacology Biochemistry and Behavior. 2011,97(4): 656-659.