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Cryptofolione

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Chemical Structure| 160098-78-2 同义名 : -
CAS号 : 160098-78-2
货号 : A621676
分子式 : C19H22O4
纯度 : 98%
分子量 : 314.376
MDL号 : MFCD32644960
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Cryptofolione, a natural product isolated and purified from the fruits of Cryptocarya alba, acts as highly efficacious inhibitors of the G(2) checkpoint, G(2) checkpoint inhibitor can force cells arrested in G(2) phase by DNA damage to enter mitosis, and shows moderate cytotoxicity in both macrophages and T. cruzi amastigotes, it also displays a mild inhibitory effect on the promastigote form of Leishmania spp.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.18mL

0.64mL

0.32mL

15.90mL

3.18mL

1.59mL

31.81mL

6.36mL

3.18mL
参考文献

[1]Sturgeon CM, Cinel B, et al. Abrogation of ionizing radiation-induced G2 checkpoint and inhibition of nuclear export by Cryptocarya pyrones. Cancer Chemother Pharmacol. 2008 Mar;61(3):407-13.

[2]Schmeda-Hirschmann G, Astudillo L, et al. Cryptofolione derivatives from Cryptocarya alba fruits. J Pharm Pharmacol. 2001 Apr;53(4):563-7.