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Arundic Acid

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Chemical Structure| 185517-21-9 同义名 : ONO-2506;(R)-2-Propyloctanoic acid;Proglia;ONO-2506PO;MK-0724;Cereact;Arocyte
CAS号 : 185517-21-9
货号 : A621199
分子式 : C11H22O2
纯度 : 98%
分子量 : 186.291
MDL号 : MFCD08458423
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 145 mg/mL(778.35 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ONO-2506 is an astrocyte-modulating agent that suppresses astrocyte activation via inhibiting the synthesis of S-100β and thereby delaying the expansion of cerebral infarcts. It exhibits therapeutic potential for stroke and Alzheimer’s disease[1]. ONO-2506 at concentrations between 30 to 300mmol/L significantly inhibited the mRNA expression and decreased the intracellular levels of S-100β. Repeated intravenous injection with ONO-2506 (50mg/kg) for 4 weeks induced inflammatory responses at the injection site and transient ataxic gait in both rats and dogs[3]. In a mouse model of MPTP-induced Parkinson’s disease, treatment with ONO-2506 (30mg/kg, i.p.) at 1min, 6h, 24h, 48h, and 72h after the last MPTP injection prevented dopamine depletion and the appearance of motor abnormalities in behavioral tests. Compared to mice injected with MPTP alone, ONO-2506 administration increased tyrosine hydroxylase-containing dopaminergic neurons in the substantia nigra (87% reduction vs. 56% reduction). ONO-2506 treatment also induced an earlier appearance of reactive astrocytes by three days and suppressed the expression of S-100β in MPTP-injected mice[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.37mL

1.07mL

0.54mL

26.84mL

5.37mL

2.68mL

53.68mL

10.74mL

5.37mL
参考文献

[1]Haasegawa, T., Kawanaka, Y., Kasamatsu, E. et al. Process Development of ONO-2506:  A Therapeutic Agent for Stroke and Alzheimer's Disease. Org. Proc. Res. Dev. 2003, 7((2): 168-171.

[2]Kato H, et al. Arundic acid, an astrocyte-modulating agent, protects dopaminergic neurons against MPTPneurotoxicity in mice. Brain Res. 2004 Dec 24;1030(1):66-73.

[3]Asano T, Mori T, Shimoda T, et al. Arundic acid (ONO-2506) ameliorates delayed ischemic brain damage by preventing astrocytic overproduction of S100B. Curr Drug Targets CNS Neurol Disord. 2005;4(2):127-142.

[4]Kato H, Kurosaki R, Oki C, Araki T. Arundic acid, an astrocyte-modulating agent, protects dopaminergic neurons against MPTP neurotoxicity in mice. Brain Res. 2004;1030(1):66-73.