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Ailanthone

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Chemical Structure| 981-15-7 同义名 : Δ13-Dehydrochaparrinone;AIL;Δ13-Dehydrochaparrinone, Ailanthone
CAS号 : 981-15-7
货号 : A619453
分子式 : C20H24O7
纯度 : 98%
分子量 : 376.4
MDL号 : MFCD01729487
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(132.84 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • PI3K
描述 Ailanthone (Δ13-Dehydrochaparrinone) is a potent inhibitor of both full-length androgen receptor (AR) (IC50=69 nM) and constitutively active truncated AR splice variants (AR1-651 IC50=309 nM)[3]. Ailanthone triggered DNA damage characterized by activation of the ATM/ATR pathway. Moreover, ailanthone-induced cell death was associated with apoptosis, as evidenced by an increased ratio of cells in the subG1 phase and by PARP cleavage and caspase activation. Ailanthone inhibited the growth and angiogenesis of tumor xenografts without significant secondary adverse effects, indicating its safety for treating HCC (anti-hepatocellular carcinoma)[4]. Ailanthone induces cell cycle arrest via the PI3K-Akt signaling pathway as well as cell apoptosis via the mitochondria-mediated apoptotic signaling pathway[5]. AIL (Ailanthone) suppresses the activity of colon cancer cells via the STAT3 pathway[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.66mL

0.53mL

0.27mL

13.28mL

2.66mL

1.33mL

26.57mL

5.31mL

2.66mL
参考文献

[1]Pedersini C, Bergamin M, et al. Herbicide activity of extracts from Ailanthus altissima (Simaroubaceae). Nat Prod Commun. 2011 May;6(5):593-6.

[2]Kato T, Suzumura Y, et al. Antitumor activity of novel ailanthone derivatives in vitro and in vivo. Anticancer Res. 1988 Jul-Aug;8(4):573-9.

[3]He Y, Peng S, Wang J, Chen H, Cong X, Chen A, Hu M, Qin M, Wu H, Gao S, Wang L, Wang X, Yi Z, Liu M. Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer. Nat Commun. 2016 Dec 13;7:13122

[4]Zhuo Z, Hu J, Yang X, Chen M, Lei X, Deng L, Yao N, Peng Q, Chen Z, Ye W, Zhang D. Ailanthone Inhibits Huh7 Cancer Cell Growth via Cell Cycle Arrest and Apoptosis In Vitro and In Vivo. Sci Rep. 2015 Nov 3;5:16185

[5]Liu W, Liu X, Pan Z, Wang D, Li M, Chen X, Zhou L, Xu M, Li D, Zheng Q. Ailanthone Induces Cell Cycle Arrest and Apoptosis in Melanoma B16 and A375 Cells. Biomolecules. 2019 Jul 11;9(7):275

[6]Ding H, Yu X, Yan Z. Ailanthone suppresses the activity of human colorectal cancer cells through the STAT3 signaling pathway. Int J Mol Med. 2022 Feb;49(2):21