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GGTI298 Trifluoroacetate

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Chemical Structure| 1217457-86-7 同义名 : GGTI 298 (trifluoroacetate salt);GGTI 298 TFA salt
CAS号 : 1217457-86-7
货号 : A618355
分子式 : C29H34F3N3O5S
纯度 : 98%+
分子量 : 593.658
MDL号 : MFCD06409252
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(176.87 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • Transferase
描述 GGTI298 trifluoroacetate is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.68mL

0.34mL

0.17mL

8.42mL

1.68mL

0.84mL

16.84mL

3.37mL

1.68mL
参考文献

[1]Sun J, Qian Y, et al. The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors. A potential mechanism for GGTI-298 antitumor activity. J Biol Chem. 1999 Mar 12;274(11):6930-4.

[2]Stark WW Jr, Blaskovich MA, et al. Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells. Am J Physiol. 1998 Jul;275(1Pt 1):L55-63.