(+)-(3R,8S)-Falcarindiol

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Chemical Structure| 225110-25-8 同义名 : 3(R),8(S),9(Z)-Falcarindiol;Falcarindiol;(3R,8S)-Falcarindiol
CAS号 : 225110-25-8
货号 : A616303
分子式 : C17H24O2
纯度 : 99%+
分子量 : 260.371
MDL号 : N/A
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 145 mg/mL(556.9 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • JNK
描述 (+)-(3R,8S)-Falcarindiol, a natural product isolated and purified from the roots of Angelica sinensis, is a potential anticancer agent that exerts its activity through inducing ER stress and apoptosis, and induces immunosuppressive effects in vitro and in vivo and might be a therapy for autoimmune or allergic diseases. It has protective effect against CCl(4) toxicity, in part, be explained by anti-lipid peroxidation activity associated with the induction of the GSTs including GSTA4.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.84mL

0.77mL

0.38mL

19.20mL

3.84mL

1.92mL

38.41mL

7.68mL

3.84mL
参考文献

[1]Yoshida J, Seino H, et al. Inhibition of glycogen synthase kinase-3β by falcarindiol isolated from Japanese Parsley (Oenanthe javanica). J Agric Food Chem. 2013 Aug 7;61(31):7515-21.

[2]Seljasen R, Vogt G, et al. Influence of field attack by carrot psyllid (Trioza apicalis Forster) on sensory quality, antioxidant capacity and content of terpenes, falcarindiol and 6-methoxymellein of carrots (Daucus carota L.). J Agric Food Chem. 2013 Mar 20;61(11):2831-8.