产品说明书

Oxysophoridine

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Chemical Structure| 54809-74-4 同义名 : Sophoridine N-oxide
CAS号 : 54809-74-4
货号 : A615114
分子式 : C15H24N2O2
纯度 : 98%
分子量 : 264.363
MDL号 : MFCD00210339
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(94.57 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Oxysophoridine is a natural product isolated and purified from the herb of Sophora alopecuroidos L. with a protective effect on focal cerebral ischemic injury through antioxidant and anti-apoptotic mechanisms. Oxysophoridine ameliorates cardiac damage in a rat model of AMI and that this cardioprotection may be linked with its anti-oxidative, anti-apoptotic and anti-inflammatory properties. Oxysophoridine may be a potential neuroprotective agent for cerebral ischemia injury, that the effect may be due to its ability to inhibit oxidative stress and expression of the N-methyl-D-aspartate receptor subunit NR1.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.78mL

0.76mL

0.38mL

18.91mL

3.78mL

1.89mL

37.83mL

7.57mL

3.78mL
参考文献

[1]Fu J, Wang Y, et al. Anti-inflammatory and anti-apoptotic effects of oxysophoridine on lipopolysaccharide-induced acute lung injury in mice. Am J Transl Res. 2015 Dec 15;7(12):2672-82.

[2]Rui C, Yuxiang L, et al. Anti-apoptotic and neuroprotective effects of oxysophoridine on cerebral ischemia both in vivo and in vitro. Planta Med. 2013 Jul;79(11):916-23.