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Moronic acid

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Chemical Structure| 6713-27-5 同义名 : (+)-Moronic acid
CAS号 : 6713-27-5
货号 : A613540
分子式 : C30H46O3
纯度 : 98+%
分子量 : 454.685
MDL号 : MFCD11113464
存储条件:

粉末

液体 -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 Moronic acid, a natural product isolated and purified from the herbs of Rhus chinensis, shows oral therapeutic efficacy in HSV-infected mice and possessed anti-HSV activity, and inhibits the capacity of Rta to activate a promoter that contains an Rta-response element, indicating that Moronic acid interferes with the function of Rta. It is a structural lead for anti-EBV drug development, can substantially reduce the numbers of EBV particles produced by the cells after lytic induction.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.20mL

0.44mL

0.22mL

11.00mL

2.20mL

1.10mL

21.99mL

4.40mL

2.20mL

参考文献

[1]Qian K, Kuo RY, et al. Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors. J Med Chem. 2010 Apr 22;53(8):3133-41.

[2]Chang FR, Hsieh YC, et al. Inhibition of the Epstein-Barr virus lytic cycle by moronic acid. Antiviral Res. 2010 Mar;85(3):490-5.