Maropitant

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Chemical Structure| 147116-67-4 同义名 : 马罗匹坦 ;CJ-11,972
CAS号 : 147116-67-4
货号 : A612810
分子式 : C32H40N2O
纯度 : 98%
分子量 : 468.67
MDL号 : MFCD00916598
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(53.34 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Maropitant, a selective NK1 receptor blocker, is orally active. It prevents substance P from attaching to receptors in the emetic center and the chemoreceptor trigger zone (CRTZ), effectively stopping vomiting[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.13mL

0.43mL

0.21mL

10.67mL

2.13mL

1.07mL

21.34mL

4.27mL

2.13mL
参考文献

[1]Lesman SP, Boucher JF, Grover GS, et al. The pharmacokinetics of maropitant citrate dosed orally to dogs at 2 mg/kg and 8 mg/kg once daily for 14 days consecutive days. J Vet Pharmacol Ther. 2012 Nov 20.

[2]Alvillar BM, Boscan P, Mama KR, et al. Effect of epidural and intravenous use of the neurokinin-1 (NK-1) receptor antagonist maropitant on the sevoflurane minimum alveolar concentration (MAC) in dogs. Vet Anaesth Analg. 2012 Mar;39(2):201-5.