Leucomethylene blue mesylate

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Chemical Structure| 1236208-20-0 同义名 : TRx0237 mesylate;Methylene blue leuco base mesylate;LMTM;Leukomethylthioninium dihydromesylate;Leucomethylene Blue;Hydromethylthionine;TRx0237 (mesylate);Hydromethylthionine mesylate
CAS号 : 1236208-20-0
货号 : A611795
分子式 : C18H27N3O6S3
纯度 : 98%
分子量 : 477.618
MDL号 : MFCD29764308
存储条件：

Pure form Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(219.84 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 85 mg/mL(177.97 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Leucomethylene blue mesylate, a common reduced form of methylene blue, is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.09mL

0.42mL

0.21mL

10.47mL

2.09mL

1.05mL

20.94mL

4.19mL

2.09mL
参考文献

[1]Panza F, Seripa D, et al. Tau aggregation inhibitors: the future of Alzheimer's pharmacotherapy? Expert Opin Pharmacother.2016;17(4):457-61.

[2]Gaudette NF, Lodge JW. Determination of methylene blue and leucomethylene blue in male and female Fischer 344 rat urine and B6C3F1 mouse urine. J Anal Toxicol. 2005 Jan-Feb;29(1):28-33.