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Fiboflapon sodium

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Chemical Structure| 1196070-26-4 同义名 : AM-803 sodium;GSK2190915 sodium salt
CAS号 : 1196070-26-4
货号 : A610483
分子式 : C38H42N3NaO4S
纯度 : 98+%
分子量 : 659.813
MDL号 : N/A
存储条件：

粉末

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(159.14 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 GSK2190915 sodium salt is a potent FLAP(5-Lipoxygenase-activating protein) inhibitor with binding IC50 of 2.9 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.52mL

0.30mL

0.15mL

7.58mL

1.52mL

0.76mL

15.16mL

3.03mL

1.52mL
参考文献

[1]Stock NS, Bain G, et al. 5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl] -5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl] -2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor. J Med Chem. 2011 Dec 8;54(23):8013-29.

[2]Lorrain DS, Bain G, et al. Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation. Eur J Pharmacol. 2010 Aug 25;640(1-3):211-8.