产品说明书

ICA 110381

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Chemical Structure| 325457-99-6 同义名 : -
CAS号 : 325457-99-6
货号 : A608671
分子式 : C12H8Cl2N2O
纯度 : 99%+
分子量 : 267.111
MDL号 : MFCD05669575
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.74mL

0.75mL

0.37mL

18.72mL

3.74mL

1.87mL

37.44mL

7.49mL

3.74mL
参考文献

[1]Amato G, Roeloffs R, Rigdon GC, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011;2(6):481-484.