2,4-Diamino-6-hydroxypyrimidine

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Chemical Structure| 56-06-4 同义名 : DAHP
CAS号 : 56-06-4
货号 : A608015
分子式 : C4H6N4O
纯度 : 97%
分子量 : 126.117
MDL号 : MFCD08528919
存储条件：

Pure form Keep in dark place,Inert atmosphere,Room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 16 mg/mL(126.87 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 10 mg/mL(79.29 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 2,4-Diamino-6-hydroxypyrimidine specifically inhibits GTP cyclohydrolase I, which is crucial in the initial step of pterin synthesis. It impedes the formation of Tetrahydrobiopterin (BH4) and consequently reduces the production of nitric oxide (NO)[1][2]. 2,4-Diamino-6-hydroxypyrimidine, also known as DAHP, demonstrates a dose-related decrease in nitric oxide (NO) levels in chicken peritoneal macrophages (PECs) and the avian MC29 virus-transformed macrophage cell line, HD11[1]. Treatment with 2,4-Diamino-6-hydroxypyrimidine (DAHP; at a concentration of 5 mM for 24 hours) notably decreases levels of both BH4 and VCAM-1 over time in HUVEC cells. The synthesis of VCAM-1 and GTPCH proteins is reduced by 2,4-Diamino-6-hydroxypyrimidine, which is partially due to the suppression of NF-κB within the nucleus of HUVEC[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

7.93mL

1.59mL

0.79mL

39.65mL

7.93mL

3.96mL

79.29mL

15.86mL

7.93mL
参考文献

[1]Sung YJ, et al. 2,4-Diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, suppresses nitric oxide production by chicken macrophages. Int J Immunopharmacol. 1994 Feb;16(2):101-8.

[2]Kazuhisa Ikemoto, et al. 2,4-Diamino-6-hydroxypyrimidine (DAHP) suppresses cytokine-induced VCAM-1 expression on the cell surface of human umbilical vein endothelial cells in a BH(4)-independent manner. Biochim Biophys Acta. Jul-Aug 2008;1780(7-8):960-5.

[3]T Kobayashi, et al. Gastrointestinal serotonin: depletion due to tetrahydrobiopterin deficiency induced by 2,4-diamino-6-hydroxypyrimidine administration. J Pharmacol Exp Ther. 1991 Feb;256(2):773-9.